Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC014
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-15 14:22
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

old patient

tbl 1Mado1par 3x1/4, caps Madopar HBS

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 16, 'TP': 22, 'FP': 14}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 21, 'TP': 15, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.056
timePerCircleCoV 0.119306
timePerCircleSlope -0.032905
meanError 1.99915
tremorFreq 5.66406
tremorRelPower 51.4548
tremorGyroAmpMean 0.112499
tremorGyroAmpSlope -0.00573748
tremorGyroAmpCoV 0.459497
tremorCoordAmpMean 0.200437
tremorCoordAmpSlope -0.00408608
tremorCoordAmpCoV 0.31906
tremorAccAmpMean 0.187383
tremorAccAmpSlope -0.00379609
tremorAccAmpCoV 0.248452
tremorPcRelVar 0.623256
tremorPcX -0.937799
tremorPcY -0.347178

Circle Segment 1

Duration 7.32 s, Accuracy Estimate 2.041 (lower is better)

Circle Segment 2

Duration 6.76 s, Accuracy Estimate 1.797 (lower is better)

Circle Segment 3

Duration 6.24 s, Accuracy Estimate 1.439 (lower is better)

Circle Segment 4

Duration 6.24 s, Accuracy Estimate 2.388 (lower is better)

Circle Segment 5

Duration 6.76 s, Accuracy Estimate 1.299 (lower is better)

Circle Segment 6

Duration 5.36 s, Accuracy Estimate 1.832 (lower is better)

Circle Segment 7

Duration 5.2 s, Accuracy Estimate 1.65 (lower is better)

Circle Segment 8

Duration 5.68 s, Accuracy Estimate 2.529 (lower is better)

Circle Segment 9

Duration 5.68 s, Accuracy Estimate 2.279 (lower is better)

Circle Segment 10

Duration 5.32 s, Accuracy Estimate 2.737 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 18.752
timePerSpiralCoV 0.2567
timePerSpiralSlope -0.0215896
meanError 1.86243
tremorFreq 5.46875
tremorRelPower 48.1221
tremorGyroAmpMean 0.116251
tremorGyroAmpSlope 0.00202578
tremorGyroAmpCoV 0.495025
tremorCoordAmpMean 0.275518
tremorCoordAmpSlope 0.00223821
tremorCoordAmpCoV 0.395345
tremorAccAmpMean 0.232611
tremorAccAmpSlope 0.00221116
tremorAccAmpCoV 0.37997
tremorPcRelVar 0.717555
tremorPcX -0.988284
tremorPcY 0.152626

Spiral Segment 1

Duration 28.36 s, Accuracy Estimate 1.34 (lower is better)

Spiral Segment 2

Duration 19.56 s, Accuracy Estimate 1.623 (lower is better)

Spiral Segment 3

Duration 15.0 s, Accuracy Estimate 2.176 (lower is better)

Spiral Segment 4

Duration 17.6 s, Accuracy Estimate 2.087 (lower is better)

Spiral Segment 5

Duration 13.96 s, Accuracy Estimate 1.732 (lower is better)

Spiral Segment 6

Duration 13.6 s, Accuracy Estimate 2.112 (lower is better)

Spiral Segment 7

Duration 21.0 s, Accuracy Estimate 1.779 (lower is better)

Spiral Segment 8

Duration 24.52 s, Accuracy Estimate 1.826 (lower is better)

Spiral Segment 9

Duration 18.68 s, Accuracy Estimate 1.792 (lower is better)

Spiral Segment 10

Duration 15.24 s, Accuracy Estimate 2.157 (lower is better)

Elel

eDurationMean 0.54359
eDurationStd 0.148412
eDurationStdnorm 0.273023
eDurationMedian 0.5
eDurationQuartdelta 0.1275
eDurationQuartdeltanorm 0.255
eDurationKurt 5.6316
eDurationTrenddiff -0.12
eDurationTrendratio 0.791304
eWidthMean 4.98
eWidthStd 2.03409
eWidthStdnorm 0.408452
eWidthMedian 4.446
eWidthQuartdelta 2.925
eWidthQuartdeltanorm 0.657895
eWidthKurt 2.70356
eWidthTrenddiff 0.468
eWidthTrendratio 1.11429
eHeightMean 14.85
eHeightStd 4.10487
eHeightStdnorm 0.276423
eHeightMedian 15.444
eHeightQuartdelta 4.6215
eHeightQuartdeltanorm 0.299242
eHeightKurt 4.67789
eHeightTrenddiff 2.106
eHeightTrendratio 1.15
eAspectMean 0.352021
eAspectStd 0.165591
eAspectStdnorm 0.470401
eAspectMedian 0.296875
eAspectQuartdelta 0.199
eAspectQuartdeltanorm 0.670317
eAspectKurt 3.70201
eAspectTrenddiff 0.0181865
eAspectTrendratio 1.06526
eSlantMean -0.166073
eSlantStd 0.196874
eSlantStdnorm -1.18547
eSlantMedian -0.169118
eSlantQuartdelta 0.295374
eSlantQuartdeltanorm -1.74656
eSlantKurt 2.47718
eSlantTrenddiff -0.108138
eRtopMean 0.609708
eRtopStd 0.220764
eRtopStdnorm 0.362081
eRtopMedian 0.666667
eRtopQuartdelta 0.33454
eRtopQuartdeltanorm 0.501811
eRtopKurt 2.12043
eRtopTrenddiff 0.0166667
eRbotMean 1.19746
eRbotStd 0.535636
eRbotStdnorm 0.44731
eRbotMedian 1.17241
eRbotQuartdelta 0.589945
eRbotQuartdeltanorm 0.503189
eRbotKurt 5.12419
eRbotTrenddiff 0.0645624
eRrightMean 0.779574
eRrightStd 0.146781
eRrightStdnorm 0.188283
eRrightMedian 0.797753
eRrightQuartdelta 0.167828
eRrightQuartdeltanorm 0.210376
eRrightKurt 3.277
eRrightTrenddiff -0.00197816
eRleftMean 0.587823
eRleftStd 0.144708
eRleftStdnorm 0.246175
eRleftMedian 0.614583
eRleftQuartdelta 0.218526
eRleftQuartdeltanorm 0.355567
eRleftKurt 2.26049
eRleftTrenddiff 0.0223312
lDurationMean 0.750488
lDurationStd 0.298286
lDurationStdnorm 0.397457
lDurationMedian 0.65
lDurationQuartdelta 0.185
lDurationQuartdeltanorm 0.284615
lDurationKurt 7.4
lDurationTrenddiff -0.1575
lDurationTrendratio 0.788591
lWidthMean 8.50105
lWidthStd 2.91593
lWidthStdnorm 0.343008
lWidthMedian 7.605
lWidthQuartdelta 4.35825
lWidthQuartdeltanorm 0.573077
lWidthKurt 2.55998
lWidthTrenddiff 2.691
lWidthTrendratio 1.39316
lHeightMean 36.367
lHeightStd 7.80298
lHeightStdnorm 0.214562
lHeightMedian 36.504
lHeightQuartdelta 6.903
lHeightQuartdeltanorm 0.189103
lHeightKurt 6.46537
lHeightTrenddiff 4.563
lHeightTrendratio 1.13448
lAspectMean 0.239916
lAspectStd 0.081321
lAspectStdnorm 0.338956
lAspectMedian 0.225
lAspectQuartdelta 0.100242
lAspectQuartdeltanorm 0.445522
lAspectKurt 6.17738
lAspectTrenddiff -0.00648801
lAspectTrendratio 0.971905
lSlantMean -0.000973464
lSlantStd 0.0726515
lSlantStdnorm -74.6319
lSlantMedian -0.0119617
lSlantQuartdelta 0.0849715
lSlantQuartdeltanorm -7.10362
lSlantKurt 3.13914
lSlantTrenddiff -0.0235297
lRtopMean 0.745886
lRtopStd 0.136398
lRtopStdnorm 0.182866
lRtopMedian 0.763636
lRtopQuartdelta 0.206848
lRtopQuartdeltanorm 0.270873
lRtopKurt 2.41715
lRtopTrenddiff -0.0364589
lRbotMean 0.786532
lRbotStd 0.282104
lRbotStdnorm 0.358668
lRbotMedian 0.759259
lRbotQuartdelta 0.318932
lRbotQuartdeltanorm 0.420057
lRbotKurt 4.8372
lRbotTrenddiff 0.0460642
lRrightMean 0.864727
lRrightStd 0.139762
lRrightStdnorm 0.161625
lRrightMedian 0.906344
lRrightQuartdelta 0.0772549
lRrightQuartdeltanorm 0.0852379
lRrightKurt 18.8148
lRrightTrenddiff -0.0250721
lRleftMean 0.472421
lRleftStd 0.207679
lRleftStdnorm 0.439605
lRleftMedian 0.514085
lRleftQuartdelta 0.350533
lRleftQuartdeltanorm 0.681858
lRleftKurt 1.93055
lRleftTrenddiff 0.021747

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.863768
sumTouchScores 14.6841
meanMovementTime 1.06344
numTouches 17
undershootPercentage 0
overshootPercentage 17.6471

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.817338
sumTouchScores 8.17338
meanMovementTime 1.78944
numTouches 10
undershootPercentage 0
overshootPercentage 50

ZigZag

numZigzags 6
timePerZigzagMean 28.9067
timePerZigzagCoV 0.171635
timePerZigzagSlope -0.0633368
meanError 2.37452
tremorFreq 5.37109
tremorRelPower 43.9557
tremorGyroAmpMean 0.11336
tremorGyroAmpSlope -0.00371796
tremorGyroAmpCoV 0.405443
tremorCoordAmpMean 0.161529
tremorCoordAmpSlope -0.00321941
tremorCoordAmpCoV 0.348239
tremorAccAmpMean 0.136597
tremorAccAmpSlope -0.00318738
tremorAccAmpCoV 0.338725
tremorPcRelVar 0.620465
tremorPcX -0.852956
tremorPcY -0.521982

ZigZag Segment 1

Duration 32.48 s, Accuracy Estimate 2.873 (lower is better)

ZigZag Segment 2

Duration 32.92 s, Accuracy Estimate 1.961 (lower is better)

ZigZag Segment 3

Duration 25.56 s, Accuracy Estimate 2.418 (lower is better)

ZigZag Segment 4

Duration 33.84 s, Accuracy Estimate 2.409 (lower is better)

ZigZag Segment 5

Duration 27.2 s, Accuracy Estimate 2.248 (lower is better)

ZigZag Segment 6

Duration 21.44 s, Accuracy Estimate 2.338 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 14.984
timePerZigzagCoV 0.231761
timePerZigzagSlope -0.125734
zigzagHeightMean 74.9302
zigzagHeightCoV 0.0793822
zigzagHeightSlope -0.019948
meanError 0.0393256
tremorFreq 5.56641
tremorRelPower 44.9905
tremorGyroAmpMean 0.104616
tremorGyroAmpSlope -0.00148018
tremorGyroAmpCoV 0.410033
tremorCoordAmpMean 0.199709
tremorCoordAmpSlope -0.000647647
tremorCoordAmpCoV 0.349811
tremorAccAmpMean 0.166343
tremorAccAmpSlope -0.00138083
tremorAccAmpCoV 0.319671
tremorPcRelVar 0.637278
tremorPcX 0.588721
tremorPcY 0.808336

ZigZag Offset Segment 1

Duration 20.8 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 2

Duration 14.8 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 3

Duration 14.6 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 4

Duration 11.88 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 12.84 s, Accuracy Estimate 0.039 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.9155932013563459}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8923124040452279}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}